Abstract:This paper describes discovery of inhibition of Oncomelania hupensis by Leonurus heterophyllus Sweet and its biological characteristic, and evaluates inhibition effect, propagation status, adaptability as well as economic benefits in control Oncomelania hupensis. Leonurus heterophyllus Sweet is the best herbaceous plant for control of Oncomelania hupensis. Ecological control of Oncomelania hupensis is an innovation for control work over blood fluke by Leonurus heterophyllus and has an extensive developmental prospect.